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Learn about Ultram (Tramadol Hcl) may treat, uses, dosage, side effects, drug interactions, warnings, patient labeling, reviews, and related medications. Physostigmine potentiated the antinociceptive effect of a sub-maximal dose of tramadol. In primate studies, which evaluated the physical dependence and reinforcement properties of tramadol, the physical dependence of the drug was deemed to be low. There is no evidence of self-induction (see Figure.1 and Table.4 below).
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